Prof. Pau-Chung CHEN 陳保中教授

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Distinguished Professor, Institute of Environmental and Occupational Health Sciences, National Taiwan University College of Public Health
Distinguished Investigator and Director, National Institute of Environmental Health Sciences, National Health Research Institutes, Taiwan
Visiting Staff, National Taiwan University Hospital, Taiwan
Chair, 35th Annual Conference of the International Society for Environmental Epidemiology (ISEE 2023, https://www.iseeconference.org)
Link: NTU Scholars, ORCID, PubMed, Google Scholar, YouTube
Address: Room 733, 17 XuZhou Road, Taipei 10055, Taiwan
E-mail: pchen@ntu.edu.tw
Phone: +886-2-3366-8088
Fax: +886-2-3366-8734
◆  Background
I graduated in medicine from Kaohsiung Medical College in Taiwan, studied environmental and occupational medicine in the Institute of Public Health at the National Taiwan University College of Medicine, and got MSc and PhD degrees in Epidemiology and Population Health at the London School of Hygiene and Tropical Medicine in United Kingdom.

◆  Teaching
I have been working at the Institute of Environmental and Occupational Health Sciences (merged from Institute of Occupational Medicine and Industrial Hygiene and Institute of Environmental Health) of National Taiwan University College of Public Health since February 1996. Currently, I am a distinguished professor and teaching children's health and the environment, women's health and the environment, developmental origins of health and disease, and statistics in environmental and occupational health. I served as director of the Department of Environmental and Occupational Medicine at the National Taiwan University Hospital and National Taiwan University College of Medicine in 2012-2018 as well as director of the Institute of Occupational Medicine and Industrial Hygiene at the National Taiwan University College of Public Health in 2014-2019.

◆  Research
Most of our studies are based on epidemiological methods and focus on public, environmental and occupational health sciences, especially for solving emerging health issues in environmental and occupational medicine, reproductive and developmental epidemiology, children’s environmental health, and cancer causes and control. I have published more than 390 scientific articles, received the Outstanding Research Award from the Ministry of Science and Technology in Taiwan in 2015 and 2020, and have been named in the world's top 2% scientists list since 2019. I was the first chair of the Birth Cohort Consortium of Asia (BiCCA) in 2012-2014, and​ served as chair of the Scientific Committee on Reproductive Hazards in the Workplace (RHICOH), International Commission on Occupational Health (ICOH) in 2012-2018. Currently, I am also appointed as a Distinguished Investigator and Director of the National Institute of Environmental Health Sciences at the National Health Research Institutes, Taiwan.

◆  Awards
  • 2022, Outstanding Social Service Award, National Taiwan University, Taiwan
  • 2021, Outstanding Research Award, National Taiwan University, Taiwan
  • 2020-2023, Outstanding Research Award, Ministry of Science and Technology, Taiwan
  • 2020-2023, Distinguished Professor (3-year award), National Taiwan University, Taiwan
  • 2020, National Occupational Safety and Health Award - Personal Contribution Award, Ministry of Labor, Taiwan
  • 2019, Distinguished Research Award, National Taiwan University, Taiwan
  • 2018, Service Award, International Commission on Occupational Health, Dublin, Ireland
  • 2018, Outstanding Alumni Award in recognition of his distinguished achievement in science, Kaohsiung Medical University, Taiwan
  • 2018, Excellent Teaching Award (Books), National Taiwan University Hospital, Taiwan
  • 2016-2019, Distinguished Professor (3-year award), National Taiwan University, Taiwan
  • 2016, Outstanding Research Award, National Taiwan University, Taiwan
  • 2015-2018, Outstanding Research Award, Ministry of Science and Technology, Taiwan
  • 2014, Distinguished Research Award, National Taiwan University, Taiwan
  • 2011, Excellent Service Award, National Taiwan University, Taiwan
  • 2006-2019, Excellent Research Award, National Taiwan University, Taiwan
  • 2004, 2008, Excellent Teaching Award, National Taiwan University, Taiwan
  • 1998, 1999, Class A Research Award, National Science Council, Taiwan
  • 1993-1995, Overseas Research Students Awards, Committee of Vice-Chancellors and Principals of the Universities of the United Kingdom

◆  Major Achievements and Contributions

◆  Selected Publications (396 referred papers in total)
  • Environmental and Occupational Medicine
  • Melamine: Wang IJ, Chen PC, Hwang KC. Melamine and nephrolithiasis in children in Taiwan. New England Journal of Medicine 2009 Mar; 360(11): 1157-1158. PubMed
  • Air pollution: Chen PC, Lai YM, Wang JD, Yang CY, Hwang JS, Kuo HW, Hwang SL, Chan CC. Adverse effect of air pollution on respiratory health in primary school children in Taiwan. Environmental Health Perspectives 1998 Jun; 106(6): 331-335. Free Article
  • Air pollution: Chen PC, Lai YM, Chan CC, Hwang JS, Yang CY, Wang JD. Short-term effect of ozone on pulmonary function of primary schoolchildren. Environmental Health Perspectives 1999 Nov; 107(11): 921-925. Free Article
  • Polychlorinated biphenyls: Yang CY, Wang YJ, Chen PC, Tsai SJ, Guo YL. Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women. Environmental Health Perspectives 2008 May; 116(5): 599-604. Free Article
  • Perfluoroalkyl substances: Dong GH, Tung KY, Tsai CH, Liu MM, Wang D, Liu W, Jin YH, Hsieh WS, Lee YL, Chen PC. Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children. Environmental Health Perspectives 2013 Apr; 121(4): 507-513. PubMed
  • Perfluoroalkyl substances: Wang Y, Rogan WJ, Chen PC, Lien GW, Chen HY, Tseng YC, Longnecker MP, Wang SL. Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study. Environmental Health Perspectives 2014 May; 122(5): 529-534. PubMed
  • Perfluoroalkyl substances: Wang Y, Adgent M, Su PH, Chen HY, Chen PC, Hsiung CA, Wang SL. Prenatal exposure to perfluorocarboxylic acids (PFCAs) and fetal and postnatal growth in the Taiwan Maternal and Infant Cohort Study. Environmental Health Perspectives 2016 Nov;124(11): 1794-1800. PubMed
  • Shift work: Wei CF, Chen MH, Lin CC, Guo YL, Lin SJ, Laio HF, Hsieh WS, Chen PC. Association between maternal shift work and infant neurodevelopmental outcomes: results from the Taiwan Birth Cohort Study with propensity score matched analysis. International Journal of Epidemiology 2019 Oct; 48(5): 1545-1555. PubMed
  • Ethylene glycol ethers: Chen PC, Hsieh GY, Wang JD, Cheng TJ. Prolonged time to pregnancy in female workers exposed to ethylene glycol ethers in semiconductor manufacturing. Epidemiology 2002 Mar; 13(2): 191-196. PubMed
  • Asbestos: Yang HY, Shie RH, Chen PC. Pulmonary fibrosis in workers exposed to non-asbestiform tremolite asbestos minerals. Epidemiology 2013 Jan; 24(1): 143-149. PubMed
  • Perfluoroalkyl substances: Chen MH, Ha EH, Liao HF, Jeng SF, Su YN, Wen TW, Lien GW, Chen CY, Hsieh WS, Chen PC. Perfluorinated compound levels in cord blood and neurodevelopment at 2 years of age. Epidemiology 2013 Nov; 24(6): 800-808. PubMed
  • Overview: Kishi R, Zhang JJ, Ha EH, Chen PC, Tian Y, Xia Y, Tsuchiya KJ, Nakai K, Kim S, Hong SJ, Hong YC, Lee JR, Jan Mohamed HJB, Parajuli RP, Adair LS, Chong YS, Guo YL, Wang SL, Nishijo M, Kido T, Tai PT, Nandasena S. Birth Cohort Consortium of Asia: Current and Future Perspectives. Epidemiology 2017 Oct; 28(Suppl 1): S19-S34. PubMed
  • Occupational disability: Lin SH, Lee HY, Chang YY, Jang Y, Chen PC, Wang JD. Increased mortality risk for workers with a compensated, permanent occupational disability of the upper or lower extremities: A 21-year follow-up study. American Journal of Epidemiology 2010 Apr; 171(8): 917-923. PubMed
  • Asthma: Lu FL, Hsieh CJ, Caffrey JL, Lin MH, Lin YS, Lin CC, Tsai MS, Ho WC, Chen PC, Sung FC, Lin RS. Body mass index may modify asthma prevalence among low-birth-weight children. American Journal of Epidemiology 2012 Jul; 176(1): 32-42. PubMed
  • Perfluoroalkyl substances: Lin CY, Chen PC, Lin YC, Lin LY. Association among serum perfluoroalkyl chemicals, glucose homeostasis and metabolic syndrome in adolescents and adults. Diabetes Care 2009 Apr; 32(4): 702-707. Free Article
  • Acrylamide: Lin CY, Lin YC, Kuo HK, Hwang JJ, Lin JL, Chen PC, Lin LY. Association among acrylamide, blood insulin, and insulin resistance in adults. Diabetes Care 2009 Dec; 32(12): 2206-2211. Free Article
  • Perfluoroalkyl substances: Lin CY, Lin LY, Chiang CK, Wang WJ, Su YN, Hung KY, Chen PC. Investigation of the associations between low-dose serum perfluorinated chemicals and liver enzymes in US adults. American Journal of Gastroenterology 2010 Jun; 105(6): 1354-1363. PubMed
  • Perfluoroalkyl substances: Wen LL, Lin LY, Su TC, Chen PC, Lin CY. Association between serum perfluorinated chemicals and thyroid function in US adults: The National Health and Nutrition Examination Survey 2007-2010. Journal of Clinical Endocrinology and Metabolism 2013 Sep; 98(9): E1456-E1464. PubMed
  • Perfluoroalkyl substances: Lin LY, Wen LL, Su TC, Chen PC, Lin CY. Negative association between serum perfluorooctane sulfate concentration and bone mineral density in US premenopausal women: NHANES, 2005-2008. Journal of Clinical Endocrinology and Metabolism 2014 Jun; 99(6): 2173-2180. PubMed
  • Phenolic compounds: Lin CY, Shen FY, Lian GW, Chien KL, Sung FC, Chen PC, Su TC. Association between levels of serum bisphenol A, a potentially harmful chemical in plastic containers, and carotid artery intima-media thickness in adolescents and young adults. Atherosclerosis 2015 Aug; 241(2): 657-663. PubMed
  • Perfluoroalkyl substances: Lin CY, Lin LY, Wen TW, Lien GW, Wen LL, Chien KL, Hsu SHJ, Sung FC, Chen PC, Su TC. Association between levels of serum perfluorooctane sulfate and carotid artery intima-media thickness in adolescents and young adults. International Journal of Cardiology 2013 Oct; 168(4): 3309-3316. PubMed
  • Perfluoroalkyl substances: Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Chen CY, Hsu SHJ, Chien KL, Sung FC, Chen PC, Su TC. Associations between levels of serum perfluorinated chemicals and adiponectin in a young hypertension cohort in Taiwan. Environmental Science and Technology 2011 Dec; 45(24): 10691-10698. PubMed
  • Phthalates: Wang IJ, Lin CC, Lin YJ, Hsieh WS, Chen PC. Early life phthalate exposure and atopic disorders in children: a prospective birth cohort study. Environment International 2014 Jan; 62: 48-54. PubMed
  • Perfluoroalkyl substances: Su TC, Kuo CC, Hwang JJ, Lien GW, Chen MF, Chen PC. Serum perfluorinated chemicals, glucose homeostasis and the risk of diabetes in working-aged Taiwanese adults. Environment International 2016 Mar; 88: 15-22. PubMed
  • Phthalates: Lin CY, Hsieh CJ, Lo SC, Chen PC, Torng PL, Hu A, Sung FC, Su TC. Positive association between concentration of phthalate metabolites in urine and microparticles in adolescents and young adults. Environment International 2016 Jul-Aug; 92-93: 157-164. PubMed
  • Perfluoroalkyl substances: Zhou Y, Hu LW, Qian ZM, Chang JJ, King C, Paul G, Lin S, Chen PC, Lee YL, Dong GH. Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: by sex status. Environment International 2016 Sep; 94: 189-195. PubMed
  • Perfluoroalkyl substances: Lin CY, Chen PC, Lo SC, Torng PL, Sung FC, Su TC. The association of carotid intima-media thickness with serum level of perfluorinated chemicals and endothelium-platelet microparticles in adolescents and young adults. Environment International 2016 Sep; 94: 292-299. PubMed
  • Incense burning: Wei CF, Chen MH, Lin CC, Guo YL, Lin SJ, Hsieh WS, Chen PC. Household incense burning and infant gross motor development: results from the Taiwan Birth Cohort Study. Environment International 2018 Jun; 115: 110-116. PubMed
  • Perfluoroalkyl substances: Tsai MS, Chang SH, Kuo WH, Kuo CH, Li SY, Wang MY, Chang DY, Lu YS, Huang CS, Cheng AL, Lin CH, Chen PC. A case-control study of perfluoroalkyl substances and the risk of breast cancer in Taiwanese women. Environment International  2020 Sep; 142: 105850. Open Access
  • Perfluoroalkyl substances: Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Chen CY, Hsu SHJ, Chien KL, Liao CC, Sung FC, Chen PC, Su TC. The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults. Journal of Hazardous Materials 2013 Jan; 244-245: 637-644. PubMed
  • Acrylamide: Lin CY, Lee HL, Chen YC, Lin LY, Wen LL, Lien GW, Chien KL, Sung FC, Chen PC, Su TC. Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. Journal of Hazardous Materials 2013 Oct; 261: 372-377. PubMed
  • Dioxins: Ho CC, Chan CC, Chio CP, Lai YC, Chang-Chien GP, Chow JC, Watson JG, Chen LWA, Chen PC, Wu CF. Source apportionment of mass concentration and inhalation risk with long-term ambient PCDD/Fs measurements in an urban area. Journal of Hazardous Materials 2016 Nov; 317: 180-187. PubMed
  • Phthalates: Lien GW, Chen JH, Tien FW, Chen PC, Chen HW, Hwa HL, Fang CC, Weng TI, Chen PS. Dilute-and-shoot enhances sensitivity of phthalate urinary concentrations for assessing the exposure in children. Journal of Hazardous Materials 2018 Jun; 351: 124-130. PubMed
  • Air Pollution: Babaan J, Hsu FT, Wong PY, Chen PC, Guo YL, Lung SCC, Chen YC, Wu CD. A Geo-AI-based ensemble mixed spatial prediction model with fine spatial-temporal resolution for estimating daytime/nighttime/daily average ozone concentrations variations in Taiwan. Journal of Hazardous Materials 2023 Mar; 446: 130749. PubMed
  • Perfluoroalkyl substances: Qin XD, Qian Z, Vaughn MG, Huang J, Ward P, Zeng XW, Zhou Y, Zhu Y, Yuan P, Li M, Bai Z, Paul G, Hao YT, Chen W, Chen PC, Dong GH, Lee YL. Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. Environmental Pollution 2016 May; 212: 519-524. PubMed
  • Perfluoroalkyl substances: Tsai MS, Lin CC, Chen MH, Hsieh WS, Chen PC. Perfluoroalkyl substances and thyroid hormones in cord blood. Environmental Pollution 2017 Mar; 222: 543-548. PubMed
  • Phthalates: Chen SY, Hwang JS, Sung FC, Lin CY, Hsieh CJ, Chen PC, Su TC. Mono-2-ethylhexyl phthalate associated with insulin resistance and lower testosterone levels in a young population. Environmental Pollution 2017 Jun; 225: 112-117. PubMed
  • Phenolic compounds: Lin CY, Hwang YT, Chen PC, Sung FC, Su TC. Association of serum levels of 4-tertiary-octylphenol with cardiovascular risk factors and carotid intima-media thickness in adolescents and young adults. Environmental Pollution 2019 Mar; 246: 107-113. PubMed
  • Pesticides: Chiu KC, Sisca F, Ying JH, Tsai WJ, Hsieh WH, Chen PC, Liu CY. Prenatal chlorpyrifos exposure in association with PPARγ H3K4me3 and DNA methylation levels and child development. Environmental Pollution 2021 Apr; 274: 116511. PubMed
  • Perfluoroalkyl substances: Lee SH, Tseng WC, Du ZY, Lin WY, Chen MH, Lin CC, Lien GW, Liang HJ, Weng HJ, Guo YL, Chen PC, Lin CY. Lipid responses to environmental perfluoroalkyl substance exposure in a Taiwanese child cohort. Environmental Pollution 2021 Aug; 283: 117007. PubMed
  • Perfluoroalkyl substances: Ku MS, Pan WC, Huang YT, Hsieh WS, Hsu YH, Chen PC, Liu CY. Associations between prenatal exposure to perfluoroalkyl substances, hypomethylation of MEST imprinted gene and birth outcomes. Environmental Pollution 2022 Jul; 304: 119183. PubMed
  • Phthalates: Lee SH, Du ZY, Tseng WC, Lin WY, Chen MH, Lin CC, Liang HJ, Wen HJ, Guo YL, Chen PC, Lin CY. Identification of serum metabolic signatures of environmental-leveled phthalate in the Taiwanese child population using NMR-based metabolomics. Environmental Pollution 2023 Jan; 316(Pt 1): 120454. PubMed
  • Air pollution: Chen SF, Chien YH, Chen PC. The association between long-term ambient fine particulate exposure and the mortality among adult patients initiating dialysis: a retrospective nationwide cohort study in Taiwan. Environmental Pollution 2023 Jan; 316(Pt 2): 120606. PubMed
  • Review: Tsai MS, Chen MH, Lin CC, Ng S, Hsieh CJ, Liu CY, Hsieh WS, Chen PC. Children’s environmental health based on birth cohort studies of Asia. Science of the Total Environment 2017 Dec; 609: 396-409. PubMed
  • Perfluoroalkyl substances: Chen MH, Ng S, Hsieh CJ, Lin CC, Hsieh WS, Chen PC. The impact of prenatal perfluoroalkyl substances exposure on neonatal and child growth. Science of the Total Environment 2017 Dec; 607-608: 669-675. PubMed
  • Phthalates: Lin LY, Tsai MS, Chen MH, Ng S, Hsieh CJ, Lin CC, Lu FL, Hsieh WS, Chen PC. Childhood exposure to phthalates and pulmonary function. Science of the Total Environment 2018 Feb; 615: 1282-1289. PubMed
  • Phenolic compounds: Lin CC, Chien CJ, Tsai MS, Chen MH, Hsieh WS, Chen PC. Prenatal phenolic compounds exposure and neurobehavioral development at 2 and 7 years of age. Science of the Total Environment 2017 Dec; 605-606: 801-810. PubMed
  • Heavy metals: Kim BM, Chen MH, Chen PC, Park H, Ha M, Kim Y, Hong YC, Kim YJ, Ha EH. Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts. Science of the Total Environment 2017 Dec; 605-606: 1003-1010. PubMed
  • Petrochemical industry: Hsu CY, Wu PY, Chen YC, Chen PC, Guo YL, Lin YJ, Lin P. An integrated strategy by using long-term monitoring data to identify volatile organic compounds of high concern near petrochemical industrial parks. Science of the Total Environment 2022 May; 821: 153345. PubMed
  • Perfluoroalkyl substances: Lien GW, Huang CC, Wu KY, Chen MH, Lin CY, Chen CY, Hsieh WS, Chen PC. Neonatal-maternal factors and perfluoroalkyl substances in cord blood. Chemosphere 2013 Aug; 92(7): 843-850. PubMed
  • Heavy metals: Ng S, Lin CC, Jeng SF, Hwang YH, Hsieh WS, Chen PC. Mercury, APOE, and child behavior. Chemosphere 2015 Feb; 120: 123-130. PubMed
  • Perfluoroalkyl substances: Lien GW, Huang CC, Shiu JS, Chen MH, Hsieh WS, Guo YL, Chen PC. Perfluoroalkyl substances in cord blood and attention deficit/hyperactivity disorder symptoms in seven-year-old children. Chemosphere 2016 Aug; 156: 118-127. PubMed
  • ​Perfluoroalkyl substances: Wen HJ, Wang SL, Chuang YC, Chen PC, Guo YL. Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children. Chemosphere 2019 Sep; 231: 25-31. PubMed
  • Air pollution: Chen YT, Liu CL, Chen CJ, Chen MH, Chen CY, Tsao PN, Chou HC, Chen PC. Association between short-term exposure to air pollution and sudden infant death syndrome. Chemosphere 2021 May; 271: 129515. PubMed
  • Benzene: Hsu CY, Xie HX, Wong PY, Chen YC, Chen PC, Wu CD. A mixed spatial prediction model in estimating spatiotemporal variations in benzene concentrations in Taiwan. Chemosphere 2022 Aug; 301: 134758. PubMed
  • Beta-adrenergic agonists: Wang CJ, Liu HJ, Chou TC, Lin CC, Pan WH, Chen PC, Hsu JF. Simultaneous determination of eight beta-adrenergic agonists in human urine by an isotope dilution-online clean-up system coupled with liquid chromatography-tandem mass spectrometry. Chemosphere 2022 Aug; 301: 134778. PubMed
  • Air pollution: Yang CY, Wang JD, Chan CC, Chen PC, Hwang JS, Cheng MF. Respiratory and irritant health effects of a population living in a petrochemical polluted area in Taiwan. Environmental Research 1997 Aug; 74(2): 145-149. PubMed
  • Heavy metals: Lin YY, Guo YL, Chen PC, Liu JH, Wu HC, Hwang YH. Associations between petrol-station density and manganese and lead in the cord blood of newborns living in Taiwan. Environmental Research 2011 Feb; 111(2): 260-265. PubMed
  • Perfluoroalkyl substances: Wang IJ, Hsieh WS, Chen CY, Fletcher T, Lien GW, Chiang HL, Chiang CF, Wu TN, Chen PC. The effect of prenatal perfluorinated chemicals exposures on pediatric atopy. Environmental Research 2011 Aug; 111(6): 785-791. PubMed
  • Heavy metals: Lin YY, Hwang YH, Chen PC, Chen BY, Wen HR, Liu JH, Guo YL. Contribution of gestational exposure to ambient traffic air pollutants to fetal cord blood manganese. Environmental Research 2012 Jan; 112(1): 1-7. PubMed
  • Heavy metals: Lin CC, Chen YC, Su FC, Lin CM, Liao HF, Hwang YH, Hsieh WS, Jeng SF, Su YN, Chen PC. In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age. Environmental Research 2013 May; 123: 52-57. PubMed
  • Acrylamide: Lin CY, Lin LY, Chen YC, Wen LL, Chien KL, Sung FC, Chen PC, Su TC. Association between measurements of thyroid function and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. Environmental Research 2015 Jan; 136: 246-252. PubMed
  • Polychlorinated biphenyls: Li MC, Tsai PC, Chen PC, Hsieh CJ, Guo YL, Rogan WJ. Mortality after exposure to polychlorinated biphenyls and dibenzofurans: 30 years after the “Yucheng Accident”. Environmental Research 2013 Jan; 120: 71-75. PubMed
  • Polychlorinated biphenyls: Li MC, Wu HP, Yang CY, Chen PC, Lambert GH, Guo YL. Gestational exposure to polychlorinated biphenyls and dibenzofurans induced asymmetric hearing loss: Yucheng children study. Environmental Research 2015 Feb; 137: 65-71. PubMed
  • Review: Tsai MS, Chen MH, Lin CC, Liu CY, Chen PC. Children’s environmental health based on birth cohort studies of Asia (2) - air pollution, pesticides, and heavy metals. Environmental Research 2019 Dec; 179A: 108754. PubMed
  • Perfluoroalkyl substances: Kung YP, Lin CC, Chen MH, Tsai MS, Hsieh WS, Chen PC. Intrauterine exposure to per- and polyfluoroalkyl substances may harm children's lung function development. Environmental Research 2021 Jan; 192: 110178. PubMed
  • Petrochemical industry: Chin WS, Pan SC, Huang CC, Chen YC, Hsu CY, Lin P, Chen PC, Guo YL. Proximity to petrochemical industrial parks and risk of chronic glomerulonephritis. Environmental Research 2022 May; 208: 112700. PubMed
  • Petrochemical industry: Huang CC, Pan SC, Chin WS, Chen YC, Wu CD, Hsu CY, Lin P, Chen PC, Guo YL. Living proximity to petrochemical industries and the risk of attention-deficit/hyperactivity disorder in children. Environmental Research 2022 Sep; 212(Part A): 113128. PubMed
  • Air pollution: Shih P, Wu CD, Chiang TL, Chen PC, Su TC, Cheng TJ, Chen YH, Guo YL. The association between postpartum depression and air pollution during pregnancy and postpartum period: a national population study in Taiwan. Environmental Research Letters 2021 Aug; 16(8): 084021. Open Access
  • Perfluoroalkyl substances: Tsai MS, Lin CY, Lin CC, Chen MH, Hsu SHJ, Chien KL, Sung FC, Chen PC, Su TC. Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults. International Journal of Hygiene and Environmental Health 2015 Jul; 218(5): 437-443. PubMed
  • Perfluoroalkyl substances: Wang Y, Rogan WJ, Chen HY, Chen PC, Su PH, Chen HY, Wang SL. Prenatal exposure to perfluroalkyl substances and children’s IQ: The Taiwan maternal and infant cohort study. International Journal of Hygiene and Environmental Health 2015 Oct; 218(7): 639-644. PubMed
  • Phthalates: Chang JW, Liao KW, Huang CY, Huang HB, Chang WT, Jaakkola JJK, Hsu CC, Chen PC, Huang PC. Phthalate exposure increased the risk of early renal impairment in Taiwanese without type 2 diabetes mellitus. International Journal of Hygiene and Environmental Health 2020 Mar; 224: 113414. PubMed
  • Perfluoroalkyl substances: Lin TW, Chen MK, Lin CC, Chen MH, Tsai MS, Chan DC, Hung KY, Chen PC. Association between exposure to perfluoroalkyl substances and metabolic syndrome and related outcomes among older residents living near a science park in Taiwan. International Journal of Hygiene and Environmental Health 2020 Sep; 230:113607. PubMed
  • Phthalates: Liao KW, Chang WH, Chou WC, Huang HB, Waits A, Chen PC, Huang PC. Human biomonitoring reference values and characteristics of phthalate exposure in the general population of Taiwan: Taiwan Environmental Survey for Toxicants 2013-2016. International Journal of Hygiene and Environmental Health 2021 Jun; 235: 113769. PubMed
  • Incense burning: Wei CF, Lin CC, Tsai MS, Guo YL, Lin SJ, Liao HF, Hsieh WS, Chen MH, Chen PC. Associations between household incense burning and delayed motor development among preterm infants modified by gestational age and maternal educational status. Indoor Air 2021 May; 31(3): 660-672. PubMed
  • Smoking: Hsieh CJ, Jeng SF, Su YN, Liao HF, Hsieh WS, Wu KY, Chen PC. CYP1A1 modifies the effect of maternal exposure to environmental tobacco smoke on child behavior. Nicotine and Tobacco Research 2010 Nov; 12(11): 1108-1117. PubMed
  • Smoking: Hsieh CJ, Jeng SF, Wu KY, Su YN, Liao HF, Hsieh WS, Chen PC. GSTM1 modifies the effect of maternal exposure to environmental tobacco smoke on neonatal primitive reflexes. Nicotine and Tobacco Research 2011 Nov; 13(11): 1114-1122. PubMed
  • Smoking: Wei CF, Lin CC, Tsai MS, Guo YL, Lin SJ, Liao HF, Hsieh WS, Chen MH, Chen PC. Associations between infant developmental delays and secondhand smoke exposure modified by maternal prepregnancy overweight and obesity status. Nicotine and Tobacco Research 2021 Sep; 23(9): 1475-1483. PubMed
  • Perfluoroalkyl substances: Chen WL, Bai FY, Chang YC, Chen PC, Chen CY. Concentrations of perfluoroalkyl substances in foods and the dietary exposure among Taiwan general population and pregnant women. Journal of Food and Drug Analysis 2018 Jul; 26(3): 994-1004. Free Article
  • Acrylamide: Chiu SY, Lin MH, Ho WC, Lin HT, Chen PC, Huang HY. Application of food description to the food classification system: evidence of risk assessment from Taiwan as acrylamide of grain products. Journal of Food and Drug Analysis 2018 Oct; 26(4): 1312-1319. Free Article
  • Pneumoconiosis: Yang HY, Shie RH, Chang CJ, Chen PC. Development of breath test for pneumoconiosis: a case-control study. Respiratory Research 2017 Oct; 18: 178. Free Article
  • Aristolochic acids: Lai MN, Wang SM, Chen PC, Chen YY, Wang JD. Population based case-control study of Chinese herbal products containing aristolochic acid and urinary tract cancer risk. Journal of the National Cancer Institute 2010 Feb; 102(3): 179-186. Free Article
  • Aristolochic acids: Lai MN, Lai JN, Chen PC, Hsieh SC, Hu FC, Wang JD. Risks of kidney failure associated with consumption of herbal supplements containing Mu Tong or Fangchi: A population based case-control study. American Journal of Kidney Diseases 2010 Mar; 55(3): 507-518. PubMed
  • Aristolochic acids: Yang HY, Wang JD, Lo TC, Chen PC. Occupational exposure to herbs containing aristolochic acids increases the risk of urothelial carcinoma in Chinese herbalists. Journal of Urology 2013 Jan; 189(1): 48-52. PubMed
  • Aristolochic acids: Hoang ML, Chen CH, Chen PC, Roberts NJ, Dickman KG, Yun BH, Turesky RJ, Pu YS, Vogelstein B, Papadopoulos N, Grollman AP, Kinzler KW, Rosenquist TA. Aristolochic acid in the etiology of renal cell carcinoma. Cancer Epidemiology, Biomarkers and Prevention 2016 Dec; 25(12): 1600-1608. PubMed
  • Aristolochic acids: Chen CJ, Yang YH, Lin MH, Lee CP, Tsan YT, Lai MN, Yang HY, Doyle P, Ho WC, Chen PC. Herbal medicine containing aristolochic acid and the risk of primary liver cancer in patients with hepatitis C virus infection. Cancer Epidemiology, Biomarkers and Prevention 2019 Nov; 28(11): 1876-1883. PubMed
  • Aristolochic acids: Chen CJ, Yang YH, Lin MH, Lee CP, Tsan YT, Lai MN, Yang HY, Ho WC, Chen PC. Herbal medicine containing aristolochic acid and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection. International Journal of Cancer 2018 Oct; 143(7): 1578-1587. PubMed
  • Aristolochic acids: Chen CJ, Chiu WC, Tseng YH, Lin CM, Yang HY, Yang YH, Chen PC. Aristolochic acid and the risk of cancers in patients with diabetes: Nationwide population-based cohort study. Phytomedicine 2022 May; 99: 154023. PubMed
  • Polychlorinated biphenyls: Li MC, Chen PC, Tsai PC, Furue M, Onozuka D, Hagihara A, Uchi H, Takesumi Y, Guo YL. Mortality after exposure to polychlorinated biphenyls and polychlorinated dibenzofurans: a meta-analysis of two highly exposed cohorts. International Journal of Cancer 2015 Sep; 137(6): 1427-1432. PubMed
  • Toxoplasmosis: Hu IJ, Chen PC, Su FC, Hsieh CJ, Jeng SF, Liao HF, Su YN, Lin SJ, Hsieh WS. Perinatal toxoplasmosis, northern Taiwan. Emerging Infectious Diseases 2006 Sep; 12(9): 1460-1461. Free Article
  • Home environment: Wen HJ, Chen PC, Chiang TL, Lin SJ, Chuang YL, Guo YL. Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors. British Journal of Dermatology 2009 Nov; 161(5): 1166-1172. PubMed
  • Atopic dermatitis: Wang IJ, Lin TJ, Kuo CF, Lin SL, Lee YL, Chen PC. Filaggrin polymorphism P478S, IgE level, and atopic phenotypes. British Journal of Dermatology 2011 Apr; 164(4): 791-796. PubMed
  • Maternal employment: Wang IJ, Wen HJ, Chiang TL, Lin SJ, Chen PC, Guo YL. Maternal employment and atopic dermatitis in children: A prospective cohort study. British Journal of Dermatology 2013 Apr; 168(4): 794-801. PubMed
  • Air pollution: Huang C, Wen H, Chen P, Chiang T, Lin S, Guo YL. Prenatal air pollutant exposure and occurrence of atopic dermatitis. British Journal of Dermatology 2015 Oct; 173(4): 981-988. PubMed
  • Home environment: Wang IJ, Guo YL, Wen HJ, Hsieh WS, Chuang YL, Lin SJ, Chen PC. Environmental risk factors for early infantile atopic dermatitis. Pediatric Allergy and Immunology 2007 Aug; 18(5): 441-447. PubMed
  • Smoking: Wang IJ, Hsieh WS, Wu KY, Guo LY, Hwang YH, Jee SH, Chen PC. Effect of gestational smoke exposure on atopic dermatitis in the offspring. Pediatric Allergy and Immunology 2008 Nov; 19(7): 580-586. PubMed
  • Breast feeding: Chuang CH, Hsieh WS, Chen YC, Chang PJ, Hurng BS, Lin SJ, Chen PC. Infant feeding practices and physician diagnosed atopic dermatitis: a prospective cohort study in Taiwan. Pediatric Allergy and Immunology 2011 Feb; 22(1 Part 1): 43-49. PubMed
  • Asthma: Huang CC, Chiang TL, Chen PC, Lin SJ, Wen HJ, Guo LY. Risk factors for asthma occurrence in children with early-onset atopic dermatitis: an 8-year follow-up study. Pediatric Allergy and Immunology 2018 March; 29(2): 159-165. PubMed
  • Smoking: Wang IJ, Guo YL, Lin TJ, Chen PC, Wu YN. GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis. Annals of Allergy, Asthma and Immunology 2010 Aug; 105(2): 124-129. PubMed
  • Atopic dermatitis: Wang IJ, Hsieh WS, Guo YL, Jee SH, Hsieh CJ, Hwang YH, Chen PC. Neuro-mediators as predictors of paediatric atopic dermatitis. Clinical and Experimental Allergy 2008 Aug; 38(8): 1302-1308. PubMed
  • Smoking: Wang IJ, Chen SL, Lu TP, Chuang EY, Chen PC. Prenatal smoke exposure, DNA methylation, and childhood atopic dermatitis. Clinical and Experimental Allergy 2013 May; 43(5): 535-543. PubMed
  • Smoking: Chen CH, Lee YL, Wu MH, Chen PJ, Wei TS, Chen PC, Tseng CI, Chen WJ. Sex moderated interactions between IL4/IL13 pathway genes and prenatal environment on cord blood IgE levels. Clinical and Experimental Allergy 2019 Aug; 49(8): 1128-1138. PubMed​
  • Pharmacoepidemiology and Outcomes Research
  • Statins: Tsan YT, Lee CH, Wang JD, Chen PC. Statins and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection. Journal of Clinical Oncology 2012 Feb; 30(6): 623-630. PubMed
  • Statins: Tsan YT, Lee CH, Ho WC, Lin MH, Wang JD, Chen PC. Statins and the risk of hepatocellular carcinoma in patients with hepatitis C virus infection. Journal of Clinical Oncology 2013 Apr; 31(12): 1514-1521. PubMed
  • Statins: Yang YH, Chen WC, Tsan YT, Chen MJ, Shih WT, Tsai YH, Chen PC. Statin use and the risk of cirrhosis development in patients with hepatitis C virus infection. Journal of Hepatology 2015 Nov; 63(5): 1111-1117. PubMed
  • Thiazolidinediones: Chen SW, Tsan YT, Chen JD, Hsieh HI, Lee CH, Lin HH, Wang JD, Chen PC, Health Data Analysis in Taiwan Research Group. Use of thiazolidinediones and the risk of colorectal cancer in patients with diabetes: A nationwide, population-based, case-control study. Diabetes Care 2013 Feb; 36(2): 369-375. PubMed
  • Alpha-glucosidase inhibitor: Tseng YH, Tsan YT, Chan WC, Sheu WHH, Chen PC. Use of an alpha-glucosidase inhibitor and the risk of colorectal cancer in patients with diabetes: a nationwide, population-based cohort study. Diabetes Care 2015 Nov; 38(11): 2068-2074. PubMed
  • Statins: Chen MJ, Tsan YT, Liou JM, Lee YC, Wu MS, Chiu HM, Wang HP, Chen PC. Statins and the risk of pancreatic cancer in type 2 diabetic patients - a population-based cohort study. International Journal of Cancer 2016 Feb; 138(3): 594-603. PubMed
  • I-131 treatment: Lin CM, Yeh PT, Doyle P, Tsan YT, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. Association between I-131 treatment for thyroid cancer and risk of receiving cataract surgery - a cohort study from Taiwan. Journal of Nuclear Medicine 2016 Jun; 57(6): 836-841. PubMed
  • I-131 treatment: Lin CM, Doyle P, Tsan YT, Lee CH, Wang JD, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. I-131 treatment for thyroid cancer and risk of developing primary hyperparathyroidism: a cohort study. European Journal of Nuclear Medicine and Molecular Imaging 2014 Feb; 41(2): 253-259. PubMed
  • Esophageal cancer: Chen MF, Yang YH, Lai CH, Chen PC, Chen WC. Outcome of patients with esophageal cancer: A nationwide analysis. Annals of Surgical Oncology 2013 Sep; 20(9): 3023-3030. PubMed
  • Statins: Wu CK, Yang YH, Lin TT, Tsai CT, Hwang JJ, Lin JL, Chen PC, Chiang FT, Lin LY. Statin use reduces the risk of dementia in elderly patients: a nationwide data survey and propensity analysis. Journal of Internal Medicine 2015 Mar; 277(3): 343-352. PubMed
  • Cardiovascular disease: Lin TT, Yang YH, Liao MT, Tsai CT, Hwang JJ, Chiang FT, Chen PC, Lin JL, Lin LY. Primary prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with end-stage renal disease undergoing dialysis. Kidney International 2015 Aug; 88(2): 378-385. PubMed
  • Hemodialysis: Lin CY, Lin LY, Chen PC. Analysis of T-wave morphology from the 12-lead electrocardiogram for prediction of long-term prognosis in patients initiating haemodialysis. Nephrology Dialysis Transplantation 2007 Sep; 22(9): 2645-2652. PubMed
  • Hemodialysis: Tsai HB, Chen PC, Liu CH, Hung PH, Chen MT, Chiang CK, Kao JH, Hung KY. Association of hepatitis C virus infection and malnutrition-inflammation complex syndrome in maintenance hemodialysis patients. Nephrology Dialysis Transplantation 2012 Mar; 27(3): 1176-1183. PubMed
  • Type 1 diabetes: Lin YH, Chen KJ, Peng YS, Chen PC, Yang YH. Type 1 diabetes impairs female fertility even before it is diagnosed. Diabetes Research and Clinical Practice 2018 Sep; 143: 151-158. Free Article
  • Depression: Sun CF, Chiu WC, Chen PC, Chang HC, Guu TW, Shityakov S, Miller AH, Felger JC, Chang JPC, Su KP. Depression-free after interferon-α exposure indicates less incidence of depressive disorder: a longitudinal study in Taiwan. Brain, Behavior, and Immunity 2020 Aug; 88: 125-131. PubMed
  • Depression: Chiu WC, Su YP, Su KP, Chen PC. Recurrence of depressive disorders after interferon-induced depression. Translational Psychiatry 2017 Feb; 7(2): e1026. Free Article
  • Depression: Lee HC, Chiu WC, Wang TN, Liao YT, Chien IC, Lee Y, McIntyre RS, Chen PC, Chen VC. Antidepressants and colorectal cancer: a population-based nested case-control study. Journal of Affective Disorders 2017 Jan; 207: 353-358. PubMed
  • Depression: Chen ACC, Huang KL, Chen HM, Chen PC, Chen VCH, Chiu WC. Antidepressants and the risk of myocardial infarction among patients with diabetes: a population-based cohort study. Journal of Affective Disorders 2021 Nov; 294: 109-114. PubMed
  • Depression: Chen SF, Chien YH, Chen PC, Wang IJ. Association of age with risk of major depression among patients with chronic kidney disease over midlife: a nationwide cohort study in Taiwan. International Psychogeriatrics 2019 Aug; 31(8): 1171-1179. PubMed
  • Dementia: Chiu WC, Tsan YT, Tsai SL, Chang CJ, Wang JD, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. Hepatitis C viral infection and the risk of dementia. European Journal of Neurology 2014 Aug; 21(8): 1068-1077. PubMed
  • Dementia: Chiu WC, Ho WC, Liao DL, Lin MH, Chiu CC, Su YP, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. Progress of diabetic severity and risk of dementia. Journal of Clinical Endocrinology and Metabolism 2015 Aug; 100(8): 2899-2908. PubMed
  • Cardiovascular disease: Huang CY, Yang YH, Lin LY, Tsai CT, Hwang JJ, Chen PC, Lin JL. Renin-angiotensin-aldosterone blockade reduces atrial fibrillation in hypertrophic cardiomyopathy. Heart 2018 Aug; 104(15): 1276-1283. PubMed
  • Cardiovascular disease: Lin LY, Lee CH, Yu CC, Tsai CT, Lai LP, Hwang JJ, Chen PC, Lin JL. Risk factors and incidence of ischemic stroke in Taiwanese with nonvalvular atrial fibrillation – a nation wide database analysis. Atherosclerosis 2011 Jul; 217(1): 292-295. PubMed
  • Cardiovascular disease: Wu CK, Huang YT, Lee JK, Juang JMJ, Tsai CT, Lai LP, Hwang JJ, Chiang FT, Lin JL, Chen PC, Lin LY. Anti-anxiety drugs use and cardiovascular outcomes in patients with myocardial infarction: A national wide assessment. Atherosclerosis 2014 Aug; 235(2): 496-502. PubMed
  • Systemic lupus erythematosus: HH, Chen PC, Yang YH, Wang LC, Lee JH, Lin YT, Chiang BL. Statin reduces mortality and morbidity in systemic lupus erythematosus patients with hyperlipidemia: a nationwide population-based cohort study. Atherosclerosis 2015 Nov: 243(1): 11-18. PubMed
  • Cardiovascular disease: Lin LY, Chen JJ, Lee CH, Hwang JJ, Liau CS, Chen PC, Lin JL. Incidence and predictors of sudden death in patients having myocardial infarction - A population-based investigation in Taiwanese. International Journal of Cardiology 2012 Jun; 157(3): 439-440. PubMed
  • Cardiovascular disease: Chen JJ, Lin LY, Yang YH, Hwang JJ, Chen PC, Lin JL. Anti-platelet or anti-coagulant agent for the prevention of ischemic stroke in patients with end-stage renal disease and atrial fibrillation - A nation-wide database analyses. International Journal of Cardiology 2014 Dec; 177(3): 1008-1011. PubMed
  • Cardiovascular disease: Ho LT, Lin LY, Yang YH, Wu CK, Juang JMJ, Wang YC, Tsai CT, Lai LP, Hwang JJ, Chiang FT, Lin JL, Chen PC. Statin therapy lowers the risk of new-onset atrial fibrillation in patients with end-stage renal disease. International Journal of Cardiology 2015 Dec; 201: 538-543. PubMed
  • Cardiovascular disease: Chung YW, Yang YH, Wu CK, Yu CC, Juang JMJ, Wang YC, Tsai CT, Lin LY, Lai LP, Hwang JJ, Chiang FT, Chen PC, Lin JL. Spironolactone is associated with reduced risk of new-onset atrial fibrillation in patients receiving renal replacement therapy. International Journal of Cardiology 2016 Jan; 202: 962-966. PubMed
  • Cardiovascular disease: Chen JJ, Lin LY, Yang YH, Hwang JJ, Chen PC, Lin JL, Chi NH. On pump versus off pump coronary artery bypass grafting in patients with end-stage renal disease and coronary artery disease - A nation-wide, propensity score matched database analyses. International Journal of Cardiology 2017 Jan; 227: 529-534. PubMed
  • Cardiovascular disease: Huang CY, Lin TT, Yang YH, Lin LY, Tsai CT, Hwang JJ, Chen PC, Lin JL. Effect of statin therapy on the prevention of new-onset acute coronary syndrome in patients with rheumatoid arthritis. International Journal of Cardiology 2018 Feb; 253: 1-6. PubMed
  • COPD and asthma: ​Su VY, Yang KY, Yang YH, Tsai YH, Perng DW, Su WJ, Chou KT, Su KC, Yen YF, Chen PC. Use of ICS/LABA combinations or LAMA is associated with a lower risk of acute exacerbation in patients with coexistent COPD and asthma. Journal of Allergy and Clinical Immunology: In Practice 2018 Nov-Dec; 6(6): 1927-1935.e3. PubMed
  • COPD and heart failure: Su VY, Yang YH, Perng DW, Tsai YH, Chou KT, Su KC, Su WJ, Chen PC, Yang KY. Real-world effectiveness of medications on survival in patients with COPD-heart failure overlap. Aging-US 2019 Jun; 11(11): 3650-3667. Free Article
  • Sepsis: Chang CM, Hsieh MS, Yang CJ, How CK, Chen PC, Meng YH. Effects of empiric antibiotic treatment based on hospital cumulative antibiograms in sepsis patients with bacteremia: A retrospective cohort study. Clinical Microbiology and Infection 2023; epub ahead of print. PubMed
  • Carbon monoxide poisoning: Meng YH, Hsieh MS, Chi YC, How CK, Chen PC​, Chang CM. Effect of carbon monoxide poisoning on epilepsy development: a nationwide population-based cohort study. Annals of Emergency Medicine 2023; epub ahead of print. PubMed
    Case-crossover design: Lee CH, Wang JD, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. Case-crossover design: an alternative strategy for detecting drug-induced liver injury. Journal of Clinical Epidemiology 2012 May; 65(5): 560-567. PubMed
  • Data Resource Profile: Lin LY, Warren-Gash C, Smeeth L, Chen PC. Data resource profile: the National Health Insurance Research Database (NHIRD). Epidemiology and Health 2018; 40 e2018062. Free Article
  • Data Resource Profile: Tsai MS, Lin MH, Lee CP, Yang YH, Chen WC, Chen PC, Tsai YH. Chang Gung Research Database: A multi-institutional database consisting of original medical records. Biomedical Journal 2017 Oct; 40(5): 263-269. Free Article