Prof. Pau-Chung CHEN 陳保中教授

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Distinguished Professor, National Taiwan University
Director, Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health
Director, Office of Occupational Safety and Health, National Taiwan University Hospital
President, Taiwan Public Health Association
Link: PubMed, ORCID, Academic Hub
Address: Room 733, 17 XuZhou Road, Taipei 10055, Taiwan
E-mail: pchen@ntu.edu.tw
Phone: +886-2-3366-8088
Fax: +886-2-3366-8734
◆  Background
I graduated in medicine from Kaohsiung Medical College in Taiwan, studied environmental and occupational medicine in the Institute of Public Health at the National Taiwan University College of Medicine, and got MSc and PhD degrees in Epidemiology and Population Health at the London School of Hygiene and Tropical Medicine in United Kingdom.

◆  Teaching
I have been working at the Institute of Occupational Medicine and Industrial Hygiene of National Taiwan University College of Public Health since February 1996 and have been appointed as the director since August 2014. Currently I am a professor and teaching children's health and the environment, women's health and the environment, developmental origins of health and disease, and statistics in environmental and occupational health. I served as director of the Department of Environmental and Occupational Medicine at the National Taiwan University Hospital and National Taiwan University College of Medicine in 2012-2018.

◆  Research
Most of my studies are based on epidemiological methods and focus on occupational and environmental medicine, reproductive and developmental epidemiology, children's environmental health, and cancer chemoprevention. Also, I'm interested in maternal, reproductive and child health, and secondary data analysis. I have published more than 300 scientific articles and received the Distinguished Research Award from the Ministry of Science and Technology in Taiwan. I was the first chair of the Birth Cohort Consortium of Asia (BiCCA) in 2012-2014, and​ served as chair of the Scientific Committee on Reproductive Hazards in the Workplace (RHICOH), International Commission on Occupational Health (ICOH) in 2012-2018. 

◆  Selected Publications (341 referred papers in total)
  • Environmental and Occupational Medicine
  • Wang IJ, Chen PC, Hwang KC. Melamine and nephrolithiasis in children in Taiwan. New England Journal of Medicine 2009 Mar; 360(11): 1157-1158. PubMed
  • Chen PC, Lai YM, Wang JD, Yang CY, Hwang JS, Kuo HW, Hwang SL, Chan CC. Adverse effect of air pollution on respiratory health in primary school children in Taiwan. Environmental Health Perspectives 1998 Jun; 106(6): 331-335. Free Article
  • Chen PC, Lai YM, Chan CC, Hwang JS, Yang CY, Wang JD. Short-term effect of ozone on pulmonary function of primary schoolchildren. Environmental Health Perspectives 1999 Nov; 107(11): 921-925. Free Article
  • Yang CY, Wang YJ, Chen PC, Tsai SJ, Guo YL. Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women. Environmental Health Perspectives 2008 May; 116(5): 599-604. Free Article
  • Dong GH, Tung KY, Tsai CH, Liu MM, Wang D, Liu W, Jin YH, Hsieh WS, Lee YL, Chen PC. Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children. Environmental Health Perspectives 2013 Apr; 121(4): 507-513. PubMed
  • Wang Y, Rogan WJ, Chen PC, Lien GW, Chen HY, Tseng YC, Longnecker MP, Wang SL. Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study. Environmental Health Perspectives 2014 May; 122(5): 529-534. PubMed
  • Wang Y, Adgent M, Su PH, Chen HY, Chen PC, Hsiung CA, Wang SL. Prenatal exposure to perfluorocarboxylic acids (PFCAs) and fetal and postnatal growth in the Taiwan Maternal and Infant Cohort Study. Environmental Health Perspectives 2016 Nov;124(11): 1794-1800. PubMed
  • Wei CF, Chen MH, Lin CC, Guo YL, Lin SJ, Laio HF, Hsieh WS, Chen PC. Association between maternal shift work and infant neurodevelopmental outcomes: results from the Taiwan Birth Cohort Study with propensity score matched analysis. International Journal of Epidemiology 2019; epub ahead of print. PubMed
  • Chen PC, Hsieh GY, Wang JD, Cheng TJ. Prolonged time to pregnancy in female workers exposed to ethylene glycol ethers in semiconductor manufacturing. Epidemiology 2002 Mar; 13(2): 191-196. PubMed
  • Yang HY, Shie RH, Chen PC. Pulmonary fibrosis in workers exposed to non-asbestiform tremolite asbestos minerals. Epidemiology 2013 Jan; 24(1): 143-149. PubMed
  • Chen MH, Ha EH, Liao HF, Jeng SF, Su YN, Wen TW, Lien GW, Chen CY, Hsieh WS, Chen PC. Perfluorinated compound levels in cord blood and neurodevelopment at 2 years of age. Epidemiology 2013 Nov; 24(6): 800-808. PubMed
  • Kishi R, Zhang JJ, Ha EH, Chen PC, Tian Y, Xia Y, Tsuchiya KJ, Nakai K, Kim S, Hong SJ, Hong YC, Lee JR, Jan Mohamed HJB, Parajuli RP, Adair LS, Chong YS, Guo YL, Wang SL, Nishijo M, Kido T, Tai PT, Nandasena S. Birth Cohort Consortium of Asia: Current and Future Perspectives. Epidemiology 2017 Oct; 28(Suppl 1): S19-S34. PubMed
  • Lin SH, Lee HY, Chang YY, Jang Y, Chen PC, Wang JD. Increased mortality risk for workers with a compensated, permanent occupational disability of the upper or lower extremities: A 21-year follow-up study. American Journal of Epidemiology 2010 Apr; 171(8): 917-923. PubMed
  • Lu FL, Hsieh CJ, Caffrey JL, Lin MH, Lin YS, Lin CC, Tsai MS, Ho WC, Chen PC, Sung FC, Lin RS. Body mass index may modify asthma prevalence among low-birth-weight children. American Journal of Epidemiology 2012 Jul; 176(1): 32-42. PubMed
  • Lin CY, Lin LY, Chiang CK, Wang WJ, Su YN, Hung KY, Chen PC. Investigation of the associations between low-dose serum perfluorinated chemicals and liver enzymes in US adults. American Journal of Gastroenterology 2010 Jun; 105(6): 1354-1363. PubMed
  • Lin CY, Chen PC, Lin YC, Lin LY. Association among serum perfluoroalkyl chemicals, glucose homeostasis and metabolic syndrome in adolescents and adults. Diabetes Care 2009 Apr; 32(4): 702-707. Free Article
  • Lin CY, Lin YC, Kuo HK, Hwang JJ, Lin JL, Chen PC, Lin LY. Association among acrylamide, blood insulin, and insulin resistance in adults. Diabetes Care 2009 Dec; 32(12): 2206-2211. Free Article
  • Wen LL, Lin LY, Su TC, Chen PC, Lin CY. Association between serum perfluorinated chemicals and thyroid function in US adults: The National Health and Nutrition Examination Survey 2007-2010. Journal of Clinical Endocrinology and Metabolism 2013 Sep; 98(9): E1456-E1464. PubMed
  • Lin LY, Wen LL, Su TC, Chen PC, Lin CY. Negative association between serum perfluorooctane sulfate concentration and bone mineral density in US premenopausal women: NHANES, 2005-2008. Journal of Clinical Endocrinology and Metabolism 2014 Jun; 99(6): 2173-2180. PubMed
  • Lin CY, Lin LY, Wen TW, Lien GW, Wen LL, Chien KL, Hsu SHJ, Sung FC, Chen PC, Su TC. Association between levels of serum perfluorooctane sulfate and carotid artery intima-media thickness in adolescents and young adults. International Journal of Cardiology 2013 Oct; 168(4): 3309-3316. PubMed
  • Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Chen CY, Hsu SHJ, Chien KL, Sung FC, Chen PC, Su TC. Associations between levels of serum perfluorinated chemicals and adiponectin in a young hypertension cohort in Taiwan. Environmental Science and Technology 2011 Dec; 45(24): 10691-10698. PubMed
  • Wang IJ, Lin CC, Lin YJ, Hsieh WS, Chen PC. Early life phthalate exposure and atopic disorders in children: a prospective birth cohort study. Environment International 2014 Jan; 62: 48-54. PubMed
  • Su TC, Kuo CC, Hwang JJ, Lien GW, Chen MF, Chen PC. Serum perfluorinated chemicals, glucose homeostasis and the risk of diabetes in working-aged Taiwanese adults. Environment International 2016 Mar; 88: 15-22. PubMed
  • Lin CY, Hsieh CJ, Lo SC, Chen PC, Torng PL, Hu A, Sung FC, Su TC. Positive association between concentration of phthalate metabolites in urine and microparticles in adolescents and young adults. Environment International 2016 Jul-Aug; 92-93: 157-164. PubMed
  • Zhou Y, Hu LW, Qian ZM, Chang JJ, King C, Paul G, Lin S, Chen PC, Lee YL, Dong GH. Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: by sex status. Environment International 2016 Sep; 94: 189-195. PubMed
  • Lin CY, Chen PC, Lo SC, Torng PL, Sung FC, Su TC. The association of carotid intima-media thickness with serum level of perfluorinated chemicals and endothelium-platelet microparticles in adolescents and young adults. Environment International 2016 Sep; 94: 292-299. PubMed
  • Wei CF, Chen MH, Lin CC, Guo YL, Lin SJ, Hsieh WS, Chen PC. Household incense burning and infant gross motor development: results from the Taiwan Birth Cohort Study. Environment International 2018 Jun; 115: 110-116. PubMed
  • Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Chen CY, Hsu SHJ, Chien KL, Liao CC, Sung FC, Chen PC, Su TC. The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults. Journal of Hazardous Materials 2013 Jan; 244-245: 637-644. PubMed
  • Lin CY, Lee HL, Chen YC, Lin LY, Wen LL, Lien GW, Chien KL, Sung FC, Chen PC, Su TC. Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. Journal of Hazardous Materials 2013 Oct; 261: 372-377. PubMed
  • Ho CC, Chan CC, Chio CP, Lai YC, Chang-Chien GP, Chow JC, Watson JG, Chen LWA, Chen PC, Wu CF. Source apportionment of mass concentration and inhalation risk with long-term ambient PCDD/Fs measurements in an urban area. Journal of Hazardous Materials 2016 Nov; 317: 180-187. PubMed
  • Lien GW, Chen JH, Tien FW, Chen PC, Chen HW, Hwa HL, Fang CC, Weng TI, Chen PS. Dilute-and-shoot enhances sensitivity of phthalate urinary concentrations for assessing the exposure in children. Journal of Hazardous Materials 2018 Jun; 351: 124-130. PubMed
  • Qin XD, Qian Z, Vaughn MG, Huang J, Ward P, Zeng XW, Zhou Y, Zhu Y, Yuan P, Li M, Bai Z, Paul G, Hao YT, Chen W, Chen PC, Dong GH, Lee YL. Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. Environmental Pollution 2016 May; 212: 519-524. PubMed
  • Tsai MS, Lin CC, Chen MH, Hsieh WS, Chen PC. Perfluoroalkyl substances and thyroid hormones in cord blood. Environmental Pollution 2017 Mar; 222: 543-548. PubMed
  • Chen SY, Hwang JS, Sung FC, Lin CY, Hsieh CJ, Chen PC, Su TC. Mono-2-ethylhexyl phthalate associated with insulin resistance and lower testosterone levels in a young population. Environmental Pollution 2017 Jun; 225: 112-117. PubMed
  • Lai MN, Wang SM, Chen PC, Chen YY, Wang JD. Population based case-control study of Chinese herbal products containing aristolochic acid and urinary tract cancer risk. Journal of the National Cancer Institute 2010 Feb; 102(3): 179-186. Free Article
  • Lai MN, Lai JN, Chen PC, Hsieh SC, Hu FC, Wang JD. Risks of kidney failure associated with consumption of herbal supplements containing Mu Tong or Fangchi: A population based case-control study. American Journal of Kidney Diseases 2010 Mar; 55(3): 507-518. PubMed
  • Yang HY, Wang JD, Lo TC, Chen PC. Occupational exposure to herbs containing aristolochic acids increases the risk of urothelial carcinoma in Chinese herbalists. Journal of Urology 2013 Jan; 189(1): 48-52. PubMed
  • Chen CJ, Yang YH, Lin MH, Lee CP, Tsan YT, Lai MN, Yang HY, Ho WC, Chen PC. Herbal medicine containing aristolochic acid and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection. International Journal of Cancer 2018 Oct; 143(7): 1578-1587. PubMed
  • Li MC, Chen PC, Tsai PC, Furue M, Onozuka D, Hagihara A, Uchi H, Takesumi Y, Guo YL. Mortality after exposure to polychlorinated biphenyls and polychlorinated dibenzofurans: a meta-analysis of two highly exposed cohorts. International Journal of Cancer 2015 Sep; 137(6): 1427-1432. PubMed
  • Hu IJ, Chen PC, Su FC, Hsieh CJ, Jeng SF, Liao HF, Su YN, Lin SJ, Hsieh WS. Perinatal toxoplasmosis, northern Taiwan. Emerging Infectious Diseases 2006 Sep; 12(9): 1460-1461. Free Article
  • Wen HJ, Chen PC, Chiang TL, Lin SJ, Chuang YL, Guo YL. Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors. British Journal of Dermatology 2009 Nov; 161(5): 1166-1172. PubMed
  • Wang IJ, Lin TJ, Kuo CF, Lin SL, Lee YL, Chen PC. Filaggrin polymorphism P478S, IgE level, and atopic phenotypes. British Journal of Dermatology 2011 Apr; 164(4): 791-796. PubMed
  • Wang IJ, Wen HJ, Chiang TL, Lin SJ, Chen PC, Guo YL. Maternal employment and atopic dermatitis in children: A prospective cohort study. British Journal of Dermatology 2013 Apr; 168(4): 794-801. PubMed
  • Huang C, Wen H, Chen P, Chiang T, Lin S, Guo YL. Prenatal air pollutant exposure and occurrence of atopic dermatitis. British Journal of Dermatology 2015 Oct; 173(4): 981-988. PubMed
  • Wang IJ, Hsieh WS, Guo YL, Jee SH, Hsieh CJ, Hwang YH, Chen PC. Neuro-mediators as predictors of paediatric atopic dermatitis. Clinical and Experimental Allergy 2008 Aug; 38(8): 1302-1308. PubMed
  • Wang IJ, Chen SL, Lu TP, Chuang EY, Chen PC. Prenatal smoke exposure, DNA methylation, and childhood atopic dermatitis. Clinical and Experimental Allergy 2013 May; 43(5): 535-543. PubMed
  • Chen CH, Lee YL, Wu MH, Chen PJ, Wei TS, Chen PC, Tseng CI, Chen WJ. Sex moderated interactions between IL4/IL13 pathway genes and prenatal environment on cord blood IgE levels. Clinical and Experimental Allergy 2019; epub ahead of print. PubMed
 
  • Pharmacoepidemiology and Outcomes Research
  • Tsan YT, Lee CH, Wang JD, Chen PC. Statins and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection. Journal of Clinical Oncology 2012 Feb; 30(6): 623-630. PubMed
  • Tsan YT, Lee CH, Ho WC, Lin MH, Wang JD, Chen PC. Statins and the risk of hepatocellular carcinoma in patients with hepatitis C virus infection. Journal of Clinical Oncology 2013 Apr; 31(12): 1514-1521. PubMed
  • Yang YH, Chen WC, Tsan YT, Chen MJ, Shih WT, Tsai YH, Chen PC. Statin use and the risk of cirrhosis development in patients with hepatitis C virus infection. Journal of Hepatology 2015 Nov; 63(5): 1111-1117. PubMed
  • Chen SW, Tsan YT, Chen JD, Hsieh HI, Lee CH, Lin HH, Wang JD, Chen PC, Health Data Analysis in Taiwan Research Group. Use of thiazolidinediones and the risk of colorectal cancer in patients with diabetes: A nationwide, population-based, case-control study. Diabetes Care 2013 Feb; 36(2): 369-375. PubMed
  • Tseng YH, Tsan YT, Chan WC, Sheu WHH, Chen PC. Use of an alpha-glucosidase inhibitor and the risk of colorectal cancer in patients with diabetes: a nationwide, population-based cohort study. Diabetes Care 2015 Nov; 38(11): 2068-2074. PubMed
  • Chen MJ, Tsan YT, Liou JM, Lee YC, Wu MS, Chiu HM, Wang HP, Chen PC. Statins and the risk of pancreatic cancer in type 2 diabetic patients - a population-based cohort study. International Journal of Cancer 2016 Feb; 138(3): 594-603. PubMed
  • Lin CM, Yeh PT, Doyle P, Tsan YT, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. Association between I-131 treatment for thyroid cancer and risk of receiving cataract surgery - a cohort study from Taiwan. Journal of Nuclear Medicine 2016 Jun; 57(6): 836-841. PubMed
  • Lin CM, Doyle P, Tsan YT, Lee CH, Wang JD, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. I-131 treatment for thyroid cancer and risk of developing primary hyperparathyroidism: a cohort study. European Journal of Nuclear Medicine and Molecular Imaging 2014 Feb; 41(2): 253-259. PubMed
  • Wu CK, Yang YH, Lin TT, Tsai CT, Hwang JJ, Lin JL, Chen PC, Chiang FT, Lin LY. Statin use reduces the risk of dementia in elderly patients: a nationwide data survey and propensity analysis. Journal of Internal Medicine 2015 Mar; 277(3): 343-352. PubMed
  • Lin TT, Yang YH, Liao MT, Tsai CT, Hwang JJ, Chiang FT, Chen PC, Lin JL, Lin LY. Primary prevention of atrial fibrillation with angiotensin-converting enzyme inhibitors and angiotensin receptor blockers in patients with end-stage renal disease undergoing dialysis. Kidney International 2015 Aug; 88(2): 378-385. PubMed
  • Chiu WC, Ho WC, Liao DL, Lin MH, Chiu CC, Su YP, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. Progress of diabetic severity and risk of dementia. Journal of Clinical Endocrinology and Metabolism 2015 Aug; 100(8): 2899-2908. PubMed
  • Huang CY, Yang YH, Lin LY, Tsai CT, Hwang JJ, Chen PC, Lin JL. Renin-angiotensin-aldosterone blockade reduces atrial fibrillation in hypertrophic cardiomyopathy. Heart 2018 Aug; 104(15): 1276-1283. PubMed
  • Lin LY, Chen JJ, Lee CH, Hwang JJ, Liau CS, Chen PC, Lin JL. Incidence and predictors of sudden death in patients having myocardial infarction - A population-based investigation in Taiwanese. International Journal of Cardiology 2012 Jun; 157(3): 439-440. PubMed
  • Chen JJ, Lin LY, Yang YH, Hwang JJ, Chen PC, Lin JL. Anti-platelet or anti-coagulant agent for the prevention of ischemic stroke in patients with end-stage renal disease and atrial fibrillation - A nation-wide database analyses. International Journal of Cardiology 2014 Dec; 177(3): 1008-1011. PubMed
  • Ho LT, Lin LY, Yang YH, Wu CK, Juang JMJ, Wang YC, Tsai CT, Lai LP, Hwang JJ, Chiang FT, Lin JL, Chen PC. Statin therapy lowers the risk of new-onset atrial fibrillation in patients with end-stage renal disease. International Journal of Cardiology 2015 Dec; 201: 538-543. PubMed
  • Chung YW, Yang YH, Wu CK, Yu CC, Juang JMJ, Wang YC, Tsai CT, Lin LY, Lai LP, Hwang JJ, Chiang FT, Chen PC, Lin JL. Spironolactone is associated with reduced risk of new-onset atrial fibrillation in patients receiving renal replacement therapy. International Journal of Cardiology 2016 Jan; 202: 962-966. PubMed
  • Chen JJ, Lin LY, Yang YH, Hwang JJ, Chen PC, Lin JL, Chi NH. On pump versus off pump coronary artery bypass grafting in patients with end-stage renal disease and coronary artery disease - A nation-wide, propensity score matched database analyses. International Journal of Cardiology 2017 Jan; 227: 529-534. PubMed
  • Huang CY, Lin TT, Yang YH, Lin LY, Tsai CT, Hwang JJ, Chen PC, Lin JL. Effect of statin therapy on the prevention of new-onset acute coronary syndrome in patients with rheumatoid arthritis. International Journal of Cardiology 2018 Feb; 253: 1-6. PubMed
  • ​Su VIF, Yang KY, Yang YH, Tsai YH, Perng DW, Su WJ, Chou KT, Su KC, Yen YF, Chen PC. Use of ICS/LABA combinations or LAMA is associated with a lower risk of acute exacerbation in patients with coexistent COPD and asthma. Journal of Allergy and Clinical Immunology: In Practice 2018 Nov-Dec; 6(6): 1927-1935.e3. PubMed
  • Lee CH, Wang JD, Chen PC, Health Data Analysis in Taiwan (hDATa) Research Group. Case-crossover design: an alternative strategy for detecting drug-induced liver injury. Journal of Clinical Epidemiology 2012 May; 65(5): 560-567. PubMed
  • Chiu WC, Su YP, Su KP, Chen PC. Recurrence of depressive disorders after interferon-induced depression. Translational Psychiatry 2017 Feb; 7(2): e1026. Free Article